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Like chondrostean fish, the major immune tissues of bony fish (or teleostei) include the kidney (especially the anterior kidney), which houses many different immune cells.[34] In addition, teleost fish possess a thymus, spleen and scattered immune areas within mucosal tissues (e.g. in the skin, gills, gut and gonads). Much lik the mammalian immune system, teleost erythrocytes, neutrophils and granulocytes are believed to reside in the spleen whereas lymphocytes are the major cell type found in the thymus.[35][36] In xxxx, a lymphatic system similar to that in mammals was described in one species of teleost fish, the zebrafish. Although not conf irmed as yet, this system presumably will be where naive (unstimulated) T cells accumulate while waiting to encounter an antigen.[3 Like other animals, fish suffer from diseases and parasites. To prevent disease they have a variety of defenses. Non-specific defenses include the skin and scales, as well as the mucus layer secreted by the epidermis that traps and inhibits the growth of microorganisms. If pathogens breach these defenses, fish can develop an inflammatory response that increases blood flow to the infected region and delivers white blood cells that attempt to destroy pathogens. Specific defenses respond to particular pathogens recognised by the fish's body, i.e., an immune response.[38] In recent years, vaccines have become widely used in aquaculture and also with fish, for example furunculosis vaccines in farmed salmon and koi herpes virus in koi.[39][40]